Blog | Oxidative stress

Oxidative stress

Free radicals (H2O2, OH°, ROO°, O°2-), in excess, result in cell lesions and genetic damage – “Le vieillissement cutané, prévention et réparation” [Skin ageing, prevention and repair] – by Philippe Piccerelle, head of the Pharmaceutical, Bio-Pharmacy and Cosmetology Laboratory at Aix-Marseille University.

The external aspects of ageing can be treated by dermocosmetology, while internal aspects can be addressed with dermonutrition, which requires a specific formulation.

The selection of active ingredients is a fundamental success factor for the formulation: this helps to combat the skin’s natural ageing process and, through nutrition, to counter external factors such as exposure to the sun (damage caused by UV rays), tobacco use, alcohol, a poor diet, environmental pollution and stress. In spite of this, as people age, their skin gradually loses its main structural components, notably collagen, elastin and elements that help it to stay hydrated (hyaluronic acid). This means developing a comprehensive formulation that supports every aspect of youthfulness, notably protecting and nourishing cells.

The role of oxidative stress in skin ageing

Antioxidants are one of the first lines of defence used by our body to combat oxidative stress. There are numerous types of radicals, however the ones that concern us most in biological systems come from oxygen and are commonly known as “reactive oxygen species”. Because of its cell structure, oxygen is particularly sensitive to the formation of radicals.

Free radicals are molecules that damage (or “oxidise”) cells throughout the body, as part of a process known as oxidative stress. This is mainly caused by exposure to the sun, atmospheric pollutants, stress, lack of sleep, tobacco smoke and overconsumption of calories and sugars.

My Pure Skin Stress Oxydatif Young Old

Collagen, a protein found in the skin, is particularly sensitive to the damage caused by free radicals. When lesions appear, they cause damage to collagen protein molecules, which then recombine in a different way, in a process known as reticulation. In the case of collagen reticulation, proteins that are normally mobile become rigid and more static.

For decades, numerous studies have confirmed the involvement of free radicals and oxidisation in the ageing process, which plays a significant part in the weakening of the body’s natural antioxidant defence systems. Oxidative stress does not only result in premature ageing; it also contributes significantly to skin inflammation.

Avoiding the causes of free radicals and adopting a lifestyle that helps you to combat them helps to protect your health; but as you age, this is sometimes not sufficient to prevent oxidative stress. This is the point at which antioxidant supplementation is needed.

My Pure Skin Stress Oxydatif

Les radicaux libres (H2O2, OH°, ROO°, O°2-), en excès, entraînent des lésions cellulaires et génétiques – « Le vieillissement cutané, prévention et réparation » – par Philippe Piccerelle, chef de service du Laboratoire de pharmacie galénique, bio-pharmacie et cosmétologie de l’Université Aix-Marseille.

Les aspects externes du vieillissement sont traités par dermocosmétologie, tandis que les aspects internes sont pris en charge par la dermonutrition, qui nécessite une formulation spécifique.

La sélection des principes actifs est un élément de réussite fondamental pour la formulation : elle permet de lutter contre le processus naturel de vieillissement de la peau et, par l’intermédiaire de la nutrition, de contrer des facteurs externes tels que l’exposition au soleil (lésions dues aux rayons UV), le tabagisme, l’alcool, une mauvaise alimentation, la pollution environnementale et le stress. Malgré cela, avec l’âge, la peau perd progressivement de ses principaux composants structurels, notamment le collagène, l’élastine et les éléments rétenteurs d’hydratation (acide hyaluronique). C’est cette formulation complète qui se doit d’être élaborée, favorisant ainsi chaque critère de jeunesse, notamment la protection et la nutrition des cellules.